There are clearly situations where phenylephrine reduces the cardiac output. This has traditionally been attributed to increased afterload causing a reduction in stroke volume. Reduced stroke volume has been shown after phenylephrine boluses and in patients with heart failure (who may be unable to tolerate … See more Make no mistake, I'm not very fond of phenylephrine. I rarely use it (mostly for hypotensive atrial fibrillation). However, understanding phenylephrine is a prerequisite to … See more Poterman 2015 performed a RCT comparing norepinephrine vs. phenylephrine among sixty patients undergoing anesthesia with propofol and remifentanil. The physiologic effects of initiating either drug … See more Evidence regarding phenylephrine consists of a patchwork of often contradictory human and animal studies, based mostly on surrogate endpoints. Thus, this post is framed as an alternative viewpoint: a perspective which … See more Depending on the balance of these factors, phenylephrine can have any effect on cardiac output (increased, decreased, or unchanged). This was demonstrated by Yamazaki 1982, who administered phenylephrine to … See more WebAfter phenylephrine infusion, the shortening of IVRT was significant in Group 1 (p<0.01). Phenylephrine, which has been shown to be an alpha-1 receptor agonist in low doses and effective only on remote myocardial function, may be given with low complication rates in the early postinfarction period.
Pulmcrit - An alternative viewpoint on phenylephrine …
WebFeb 17, 2024 · Includes Phenylephrine (Systemic) indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. ... and reduced cardiac output due to an increase in cardiac afterload especially in patients with preexisting cardiac dysfunction … WebFeb 19, 2024 · Phenylephrine may cause reflex bradycardia, decreased CO, local tissue necrosis with extravasation, peripheral, renal, mesenteric, or myocardial ischemia. Vasopressin may induce arrhythmias, mesenteric … panera bread geneva il
Afterload - an overview ScienceDirect Topics
WebIncrease afterload (hypotensive only) Phenylephrine, max dose range depending on source Start at 100 mcg/min (~1.5 mcg/kg/min for average adult) Range usually 0.5 - 6.0 mcg/kg/min, with efficacy minimal beyond 6 … WebOct 13, 2024 · Phenylephrine was added when the shock was progressive, which we believe was a reasonable choice as it is a vasopressor primarily affecting the peripheral vasculature. In hindsight, it would have been more appropriate to discontinue the fluid challenge after 0.5–1 L of sodium chloride (0.9%) and start an inotropic agent and/or vasopressor ... エスレン